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Our Publications

BeatProfiler: Multimodal In Vitro Analysis of Cardiac Function Enables Machine Learning Classification of Diseases and Drugs

Y. Kim et al.

2024

BeatProfiler: Multimodal In Vitro Analysis of Cardiac Function Enables Machine Learning Classification of Diseases and Drugs

Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration

D. Chen et al.

2020

Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration

Blocking TLR4 mitigates static loading induced pro-inflammatory expression in intervertebral disc motion segments

H. Kenawy et al.

2023

Blocking TLR4 mitigates static loading induced pro-inflammatory expression in intervertebral disc motion segments

Engineered cardiac tissue model of restrictive
cardiomyopathy for drug discovery

B. Wang et al.

2023

Engineered cardiac tissue model of restrictive
cardiomyopathy for drug discovery

3D Printing of Silk Protein Structures by Aqueous Solvent-Directed Molecular Assembly

X. Mu et al.

2020

3D Printing of Silk Protein Structures by Aqueous Solvent-Directed Molecular Assembly

Red blood cell exposure increases chondrocyte susceptibility to oxidative stress following hemarthrosis

A. Lee et al.

2023

Red blood cell exposure increases chondrocyte susceptibility to oxidative stress following hemarthrosis

milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues

M. Tamargo et al.

2021

milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues

Matrix Deformation with Ectopic Cells Induced by Rotational Motion in Bioengineered Neural Tissues

N. Rouleau et al.

2020

Matrix Deformation with Ectopic Cells Induced by Rotational Motion in Bioengineered Neural Tissues

Sustained Delivery of SB-431542, a Type I Transforming Growth Factor b-1 Receptor Inhibitor, to Prevent Arthrofibrosis

A. Lee et al.

2021

Sustained Delivery of SB-431542, a Type I Transforming Growth Factor b-1 Receptor Inhibitor, to Prevent Arthrofibrosis

Rapid Volumetric Bioprinting of Decellularized Extracellular Matrix Bioinks

L. Lian et al.

2024

Rapid Volumetric Bioprinting of Decellularized Extracellular Matrix Bioinks

Sudan Black B Pretreatment to Suppress Autofluorescence in Silk Fibroin Scaffolds

O. Foster et al.

2023

Sudan Black B Pretreatment to Suppress Autofluorescence in Silk Fibroin Scaffolds

Orally delivered 2D covalent organic frameworks releasing kynurenine generate anti-inflammatory T cell responses in collagen induced arthritis mouse model

M. Jaggarapu et al.

2023

Orally delivered 2D covalent organic frameworks releasing kynurenine generate anti-inflammatory T cell responses in collagen induced arthritis mouse model

Three-Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome

M. Adelfio et al.

2023

Three-Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome

Pulsed Electromagnetic Field Therapy and Direct Current Electric Field Modulation Promote the Migration of...

N. Sakhrani et al.

2022

Pulsed Electromagnetic Field Therapy and Direct Current Electric Field Modulation Promote the Migration of...

Imaging-guided Bioreactor for De-epithelialization and Long-term cultivation of ex vivo

S. Mir et al.

2022

Imaging-guided Bioreactor for De-epithelialization and Long-term cultivation of ex vivo

Self-Folding 3D Silk Biomaterial Rolls to Facilitate Axon and Bone Regeneration

Y. Huang et al.

2020

Self-Folding 3D Silk Biomaterial Rolls to Facilitate Axon and Bone Regeneration

Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury

T. Chen et al.

2019

Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

M. Liberman et al.

2022

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Engineered Vascularized Flaps, Composed of Polymeric Soft Tissue and Live Bone, Repair Complex Tibial Defects

I. Redenski et al.

2021

Engineered Vascularized Flaps, Composed of Polymeric Soft Tissue and Live Bone, Repair Complex Tibial Defects

Emerging imaging modalities for functional assessment of donor lungs ex vivo

M. Hudock et al.

2022

Emerging imaging modalities for functional assessment of donor lungs ex vivo

Toward defining the role of the synovium in mitigating normal articular cartilage wear and tear

M. Pellicore et al.

2023

Toward defining the role of the synovium in mitigating normal articular cartilage wear and tear

Mucosa-Mimetic Materials for the Study of Intestinal Homeostasis and Disease

R. Donahue

2023

Mucosa-Mimetic Materials for the Study of Intestinal Homeostasis and Disease

Designing Biocompatible Tissue Engineered Heart Valves In Situ

E. Cordovez et al.

2023

Designing Biocompatible Tissue Engineered Heart Valves In Situ

Opportunities and Challenges in Cardiac Tissue Engineering From an Analysis of Two Decades of Advances

R. Zhuang et al.

2022

Opportunities and Challenges in Cardiac Tissue Engineering From an Analysis of Two Decades of Advances

Machine Learning Techniques to Classify Healthy and Diseased Cardiomyocytes by Contractility Profile

D. Teles et al.

2021

Machine Learning Techniques to Classify Healthy and Diseased Cardiomyocytes by Contractility Profile

RNA and Protein Delivery by Cell-Secreted and Bioengineered Extracellular Vesicles

B. Wang et al.

2021

RNA and Protein Delivery by Cell-Secreted and Bioengineered Extracellular Vesicles

Cell type–specific microRNA therapies for myocardial infarction

B. Liu et al.

2021

Cell type–specific microRNA therapies for myocardial infarction

A Framework for Developing Sex-specific Engineered Heart Models

R. Lock et al.

2021

A Framework for Developing Sex-specific Engineered Heart Models

Emerging Trajectories for Next Generation Tissue Engineers

D. Tavakol et al.

2021

Emerging Trajectories for Next Generation Tissue Engineers

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

M. Basil et al.

2020

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

Bioengineered elastin- and silk-biomaterials for drug and gene delivery

L. Chambre et al.

2020

Bioengineered elastin- and silk-biomaterials for drug and gene delivery

Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip

K. Wagner et al.

2020

Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip

Silk Hydrogels Crosslinked by the Fenton Reaction

J. Choi et al.

2019

Silk Hydrogels Crosslinked by the Fenton Reaction

Tissue engineering of the heart: An evolving paradigm

G. Vunjak-Novakovic

2017

Tissue engineering of the heart: An evolving paradigm

Directed differentiation of human iPSCs into
mesenchymal lineages by optogenetic control of TGF-b signaling

J. Wu et al.

2023

Directed differentiation of human iPSCs into
mesenchymal lineages by optogenetic control of TGF-b signaling

Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

A. Hozain et al.

2020

Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

Recovery of extracorporeal lungs using cross-circulation
with injured recipient swine

P. Chen et al.

2023

Recovery of extracorporeal lungs using cross-circulation
with injured recipient swine

STK25 Inhibits PKA Signaling by Phosphorylating PRKAR1A

X. Zhang et al.

2022

STK25 Inhibits PKA Signaling by Phosphorylating PRKAR1A

Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs

C. Sakolish et al.

2019

Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs

A Clinically-relevant Model of Acute Respiratory Distress
Syndrome in Human-size Swine

S. Kaslow et al.

2022

A Clinically-relevant Model of Acute Respiratory Distress
Syndrome in Human-size Swine

Enzyme-Mediated Conjugation of Peptides to Silk Fibroin for Facile Hydrogel Functionalization

M. McGill et al.

2020

Enzyme-Mediated Conjugation of Peptides to Silk Fibroin for Facile Hydrogel Functionalization

Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine

A. Hozain et al.

2019

Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine

Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles...

A. Villasante et al.

2021

Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles...

Modeling and countering the effects of cosmic radiation using bioengineered human tissues

D. Tavakol et al.

2023

Modeling and countering the effects of cosmic radiation using bioengineered human tissues

Optimization of Culture Media and Cell Ratios for 3D In Vitro Skeletal Muscle Tissues with Endothelial Cells

J. Yuen et al.

2023

Optimization of Culture Media and Cell Ratios for 3D In Vitro Skeletal Muscle Tissues with Endothelial Cells

Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration

H. Hirakawa et al.

2023

Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration

In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis

J. Arriaga et al.

2023

In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis

Sound-guided Assessment and Localization of Pulmonary Air Leak

M. Pinezich et al.

2022

Sound-guided Assessment and Localization of Pulmonary Air Leak

Learning and synaptic plasticity in 3D bioengineered neural tissues

N. Rouleau et al.

2021

Learning and synaptic plasticity in 3D bioengineered neural tissues

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

A. Chramiec et al.

2020

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

3D bioengineered tissue model of the large intestine to study inflammatory bowel disease

T. Roh et al.

2019

3D bioengineered tissue model of the large intestine to study inflammatory bowel disease

Technique for xenogeneic cross-circulation to support human donor lungs ex vivo

W. Wu et al.

2022

Technique for xenogeneic cross-circulation to support human donor lungs ex vivo

Challenges and opportunities for the next generation of cardiovascular tissue engineering

S. Cho et al.

2022

Challenges and opportunities for the next generation of cardiovascular tissue engineering

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

S. Fleischer et al.

2020

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

Functional bioengineered tissue models of neurodegenerative diseases

A. Mullis et al.

2023

Functional bioengineered tissue models of neurodegenerative diseases

Synthesis and characterization of silk-poly(guluronate) hybrid polymers for the fabrication of...

O. Hasturk et al.

2023

Synthesis and characterization of silk-poly(guluronate) hybrid polymers for the fabrication of...

Engineering Complexity in Human Tissue Models of Cancer

K. Ronaldson-Bouchard et al.

2022

Engineering Complexity in Human Tissue Models of Cancer

Progress in multicellular human cardiac organoids for clinical applications

H Kim et al.

2022

Progress in multicellular human cardiac organoids for clinical applications

Recent advances in 3D printing with protein-based inks

X. Mu et al.

2021

Recent advances in 3D printing with protein-based inks

Gut bioengineering strategies for regenerative medicine

J. O'Neill et al.

2021

Gut bioengineering strategies for regenerative medicine

Engineered models of tumor metastasis with immune cell contributions

P. Graney et al.

2021

Engineered models of tumor metastasis with immune cell contributions

Rheological characterization, compression, and injection molding of hydroxyapatite-silk fibroin composites

S. McNamara et al.

2021

Rheological characterization, compression, and injection molding of hydroxyapatite-silk fibroin composites

Toward Studying Cognition in a Dish

N. Rouleau et al.

2021

Toward Studying Cognition in a Dish

Characterization of silk-hyaluronic acid composite hydrogels towards vitreous humor substitutes

N. Raia et al.

2020

Characterization of silk-hyaluronic acid composite hydrogels towards vitreous humor substitutes

Synthesis and Characterization of Silk Ionomers for Layer-by-Layer Electrostatic Deposition on Individual Mammalian Cells

O. Hasturk et al.

2020

Synthesis and Characterization of Silk Ionomers for Layer-by-Layer Electrostatic Deposition on Individual Mammalian Cells

Bioengineering of Pulmonary Epithelium With Preservation of the Vascular Niche

N. Dorrello et al.

2020

Bioengineering of Pulmonary Epithelium With Preservation of the Vascular Niche

Cell armor for protection against environmental stress: Advances, challenges and applications in micro-...

O. Hasturk et al.

2019

Cell armor for protection against environmental stress: Advances, challenges and applications in micro-...

A Multi-organ Chip with Matured Tissue Niches Linked by Vascular Flow

K. Ronaldson-Bouchard et al.

2022

A Multi-organ Chip with Matured Tissue Niches Linked by Vascular Flow

Quantification of human neuromuscular function through optogenetics

O. Vila et al.

2019

Quantification of human neuromuscular function through optogenetics

Lung-mimetic Hydrofoam Sealant to Treat Pulmonary Air Leak

M. Pinezich et al.

2023

Lung-mimetic Hydrofoam Sealant to Treat Pulmonary Air Leak

Thermoplastic moulding of regenerated silk

C. Guo et al.

2020

Thermoplastic moulding of regenerated silk

Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

J. Yuen et al.

2023

Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

Bioengineered optogenetic model of human neuromuscular junction

O. Vila et al.

2021

Bioengineered optogenetic model of human neuromuscular junction

From Silk Spinning to 3D Printing: Polymer Manufacturing using Directed Hierarchical Molecular Assembly

X. Mu et al.

2020

From Silk Spinning to 3D Printing: Polymer Manufacturing using Directed Hierarchical Molecular Assembly

In vitro models of neuromuscular junctions and their potential for novel drug discovery and development

O. Vila et al.

2019

In vitro models of neuromuscular junctions and their potential for novel drug discovery and development

Tuning the Biodegradation Rate of Silk Materials via Embedded Enzymes

J. Wu et al.

2024

Tuning the Biodegradation Rate of Silk Materials via Embedded Enzymes

Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model

V. Liaudanskaya et al.

2023

Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model

Multifunctional silk vinyl sulfone-based hydrogel scaffolds for dynamic material-cell interactions

T. Falcucci et al.

2023

Multifunctional silk vinyl sulfone-based hydrogel scaffolds for dynamic material-cell interactions

Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury

H. Kenawy et al.

2023

Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury

Silk fibroin-based inks for in situ 3D printing using a double crosslinking process

F. Agostinacchio et al.

2023

Silk fibroin-based inks for in situ 3D printing using a double crosslinking process

Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading

Y. Zhao et al.

2022

Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading

Organs-on-a-chip models for biological research

G. Vunjak-Novakovic et al.

2021

Organs-on-a-chip models for biological research

Fabricating mechanically improved silk-based vascular grafts by solution control of the gel-spinning process

M. Rodriguez et al.

2019

Fabricating mechanically improved silk-based vascular grafts by solution control of the gel-spinning process

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue Rat Trachea

S. Mir et al.

2022

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue Rat Trachea

Opto-electromechanical quantification of
epithelial barrier function in injured and
healthy airway tissues

J. Chen et al.

2022

Opto-electromechanical quantification of
epithelial barrier function in injured and
healthy airway tissues

Engineering and Characterization of an Optogenetic
Model of the Human Neuromuscular Junction

M. Liberman et al.

2022

Engineering and Characterization of an Optogenetic
Model of the Human Neuromuscular Junction

Delivering on the promise of recombinant silk-inspired proteins for drug delivery

C. Gonzalez-Obeso et al.

2023

Delivering on the promise of recombinant silk-inspired proteins for drug delivery

In vitro inflammatory multi-cellular model of osteoarthritis

I. Marrero-Berrios et al.

2023

In vitro inflammatory multi-cellular model of osteoarthritis

Silk Nanoparticle Synthesis: Tuning Size, Dispersity, and Surface Chemistry for Drug Delivery

S. Shaidani et al.

2023

Silk Nanoparticle Synthesis: Tuning Size, Dispersity, and Surface Chemistry for Drug Delivery

Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization...

J. Bernhard et al.

2022

Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization...

A Guide to the Organ-on-a-Chip

C. Leung et al.

2022

A Guide to the Organ-on-a-Chip

Dynamically tunable light responsive silk-elastin-like proteins

O. Narayan et al.

2021

Dynamically tunable light responsive silk-elastin-like proteins

Bioengineering Human Cartilage–Bone Tissues for Modeling of Osteoarthritis

J. Wu et al.

2021

Bioengineering Human Cartilage–Bone Tissues for Modeling of Osteoarthritis

Pressure-driven spreadable deferoxamine-laden hydrogels for vascularized skin flaps

L. Wu et al.

2021

Pressure-driven spreadable deferoxamine-laden hydrogels for vascularized skin flaps

In Vitro Models of Intestine Innate Immunity

T. Roh et al.

2021

In Vitro Models of Intestine Innate Immunity

A framework for developing sex-specific engineered heart models

R. Lock et al.

2021

A framework for developing sex-specific engineered heart models

In Situ 3D Printing: Opportunities with Silk Inks

F. Agostinacchio et al.

2020

In Situ 3D Printing: Opportunities with Silk Inks

Harnessing organs-on-a-chip to model tissue regeneration

N. Tavakol et al.

2020

Harnessing organs-on-a-chip to model tissue regeneration

Heart regeneration in mouse and human: a bioengineering perspective

B. Fine et al.

2020

Heart regeneration in mouse and human: a bioengineering perspective

Assembly and Application of a Three-Dimensional Human Corneal Tissue Model

T. McKay et al.

2019

Assembly and Application of a Three-Dimensional Human Corneal Tissue Model

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